Job Description:

Preformulations, Staff Scientist to Principal Investigator

We are currently seeking talented individuals with Preformulation and Materials Characterization expertise to join our growing Pharmaceutical Development team.

Responsibilities include

• evaluating Physico-chemical and materials properties of small molecules and formulations, with a focus on solution and solid-state characterization and/or mechanical characterization;
• developing and evaluating small-scale formulations for oral and parenteral dosage forms for novel compounds to support PK and TK studies;
• interfacing with Basic Research and Preclinical Development to assess develop-ability of drug candidates;
• identifying and developing small scale experiments to predict robustness of formulation and process upon scale-up;
• assessing materials properties of prototype formulations, and evaluating impact of excipient and API properties on formulation performance;
• assessing impact of processing on materials properties, especially the physical state of the API;
• contributing to the development of platform technologies for controlled release solid dosage forms with the main focus on roller compaction and fluid bed granulation; and
• troubleshooting formulations and suggesting options for resolution of any issues.

Qualifications and Other Required Knowledge and Skills:

A Masters with 10+ years of related experience or a PhD with 3+ years of related experience in Pharmaceutics, Physical Chemistry or Materials Science is required, with related industry experience in preformulation and/or Materials Characterization. A thorough understanding of solution and solid-state physics and chemistry applied to small molecule organics is essential. Working knowledge in X-ray Diffraction, Solubility and solubilization, Thermal analysis, Moisture sorption, IR/Raman spectroscopy, Optical and scanning electron microscopy and Liquid chromatography is required. A strong knowledge of Wettability, Particle Size Distribution, Granular Attrition, Flow and Segregation, Mechanical Characterization and Compaction simulation is strongly desired. Knowledge in properties essential for drug discovery is desired. Working knowledge in crystallization and salt/polymorph selection is preferred. A strong knowledge of surface phenomenon and colloidal science is preferred. Working knowledge of sustained release formulations, roller compaction and/or fluid bed granulation is preferred. A strong knowledge and research expertise in the field of solid oral dosage formulation is strongly desired, from conception to full commercial utility. Ability to work independently, with excellent organizational, communication, leadership and problem solving abilities. A demonstrated publication record and strong academic performance is required, with a significant publication record preferred.